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At the age of 23 I have been on Hydrea for about two years now due to Essential Thrombocythemia and my platelets count over 2 million. I have tried many different medications for the same purpose but the majority of them caused unbearable side effects. And in spite of the fact that with Hydrea I do have some side effects - fatigue, some muscle pain and easy bruising - I can tolerate them and in addition I get so much better control over my platelets level what is a big change for me. My doctor helps me adjust my dosage and monitors my health condition. He also observes the positive effect Hydrea provides, so I am quite enthusiastic and hopeful. Would recommend Hydrea to other people with similar health condition.

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Medicine 75: 300-326, 1996.

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Some organ damage from sickle cell disease is permanent therefore will not be reversed by any treatment.

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The pain may also occur because of involvement of the periosteum or periarticular soft tissue of the joints.

It has to be borne in mind that sickling can still occur on hydroxyurea; painful crises, acute chest syndrome, splenic sequestration and neurological events have all been reported whilst receiving hydroxyurea.

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We are providing this information solely as a courtesy and, as such, it is in no way a recommendation as to the safety, efficacy or appropriateness of any particular drug, regimen, dosing schedule for any particular cancer, condition or patient nor is it in any way to be considered medical advice.

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SCD mice and even demonstrated greater efficiency in increasing leukocyte rolling and reducing WBC-RBC interactions, possibly because of the slightly higher concentration used in these experiments.

The journal acts as an international platform for sharing laboratory findings in these areas and makes a deliberate effort to publish clinical trials with 'negative' results and basic science studies with provocative findings.

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This was a case-control study of 18 patients with sickle cell disease and a history of priapism during the previous year, and 16 controls with sickle cell disease.

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The quality of life of patients with sickle cell anemia is severely compromised similar to or even worse than patients with other chronic diseases such as arthritis.

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